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fts lyostar 3 lyophilizer (ATS Scientific Inc)

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ATS Scientific Inc fts lyostar 3 lyophilizer
Fts Lyostar 3 Lyophilizer, supplied by ATS Scientific Inc, used in various techniques. Bioz Stars score: 96/100, based on 403 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lyostar+3+lyophilizer/Hull+LyoStar+4%2E0+R%26D%2FProcess+Development+Freeze+Dryer/10__1016_slash_j__celbio__2026__100410-335-10-11
Average 96 stars, based on 403 article reviews

fts lyostar 3 lyophilizer - by Bioz Stars, 2026-10

96/100 stars

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Article Title: Room temperature stable lyophilized protein
Article Snippet: The charged vial was placed into a LYOSTAR 3 lyophilizer (SP Scientific, Warminster, Pa.).

Article Title: Effects of temperature and relative humidity in D 2 O on solid-state hydrogen deuterium exchange mass spectrometry (ssHDX-MS).
Article Snippet: Lyophilized powders containing myoglobin and various excipients were subjected to ssHDX-MS at different temperatures and D2O vapor activity (RH).. Deuterium incorporation was fitted to a bi-exponential association model for each formulation and the dependence of regression parameters on temperature and RH was evaluated.. Data fitted best to a simplified model in which the slow exponential term was considered invariant with temperature and RH while the fast exponential term retained its temperature and RH dependence.

Article Title: Rapid Depressurization Based Controlled Ice Nucleation in Pharmaceutical Freeze-drying: The Roles of the Ballast Gas and the Vial.
Article Snippet: All CIN experiments were conducted in a LyoStar 3 lyophilizer (SP Scientific, Warminster, PA) outfitted with ControLyo technology.

Article Title: Rapid depressurization controlled ice nucleation in pharmaceutical freeze-drying
Article Snippet: All CIN procedure discussed herein were conducted in a LYOSTAR 3 lyophilizer (SP SCIENTIFIC, Warminster, PA) outfitted with CONTROLYO technology.

Article Title: A Compact Model for Lyophilizer Equipment Capability Estimation.
Article Snippet: This work presents a compact model for the equipment capability limit of a common configuration of pharmaceutical lyophilizers, a product chamber separated from the condenser by a duct and isolation valve, at a wide range of design parameters.. The equipment capability limit is one of the most important characteristics determining the lyophilization design space for a particular product, container, and equipment combination.. Experimental measurements of equipment capability are time-consuming and expensive, especially at the production scale.

Allele-specific Oligonucleotide:

Article Title: BP1003 Decreases STAT3 Expression and Its Pro-Tumorigenic Functions in Solid Tumors and the Tumor Microenvironment
Article Snippet: DOPC lipids were purchased from Avanti Polar Lipids, Inc. (Alabaster, AL, USA). .. STAT3 ASO was formulated with DOPC lipids and lyophilized in a LyoStar 3 lyophilizer (SP Industries, Inc., Warminster, PA, USA). ..

Article Title: BP1003 Decreases STAT3 Expression and Its Pro-Tumorigenic Functions in Solid Tumors and the Tumor Microenvironment.
Article Snippet: DOPC lipids were purchased from Avanti Polar Lipids, Inc. (Alabaster, AL, USA). .. STAT3 ASO was formulated with DOPC lipids and lyophilized in a LyoStar 3 lyophilizer (SP Industries, Inc., Warminster, PA, USA). ..

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$A photograph (left) and schematic (right) of qRF microwave lyophilization experimental setup on LyoStar \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\circledR$$\end{document} 3 freeze-dryer. Closed-loop components are marked in green.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: A photograph (left) and schematic (right) of qRF microwave lyophilization experimental setup on LyoStar \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\circledR$$\end{document} 3 freeze-dryer. Closed-loop components are marked in green.

Article Snippet: All conventional and qRF microwave lyophilization experiments are carried out in a lab-scale lyophilizer (LyoStar \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\circledR$$\end{document} 3 from SP Scientific) in the LyoHUB facility at Purdue University.

Techniques: Lyophilization

Formulations and cases considered with the corresponding measured primary drying times.

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Formulations and cases considered with the corresponding measured primary drying times.

Techniques: Formulation, Virus

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Fitting parameters used in simulations

Techniques:

Material properties used in process modeling.

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Material properties used in process modeling.

Techniques: Sublimation

$The normalized electric field distribution inside the qRF microwave chamber based on full-wave electromagnetic simulations using COMSOL for scatterer rotation angle \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\theta =0$$\end{document} and 152 degrees and excitation frequencies \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f=2.5$$\end{document} and 8 GHz.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: The normalized electric field distribution inside the qRF microwave chamber based on full-wave electromagnetic simulations using COMSOL for scatterer rotation angle \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\theta =0$$\end{document} and 152 degrees and excitation frequencies \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f=2.5$$\end{document} and 8 GHz.

Techniques:

$Experimentally measured temperatures, ( a ) and ( b ), and pressures, ( c ), for Cases M1, ( a ) and ( c ), and M2, ( b ) and ( c ), of Table . Lumped-capacitance modeling results are also shown in ( a ) and ( b ). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f1}$$\end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f2}$$\end{document} are frozen product temperatures for different center vials; \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {vw}$$\end{document} represents the temperature of the vial wall’s outer surface. Model curves terminate at the predicted end of drying. Case M1 in ( a ) was used to tune the four microwave-related parameters, and Case M2 is a validation case.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Experimentally measured temperatures, ( a ) and ( b ), and pressures, ( c ), for Cases M1, ( a ) and ( c ), and M2, ( b ) and ( c ), of Table . Lumped-capacitance modeling results are also shown in ( a ) and ( b ). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f1}$$\end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f2}$$\end{document} are frozen product temperatures for different center vials; \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {vw}$$\end{document} represents the temperature of the vial wall’s outer surface. Model curves terminate at the predicted end of drying. Case M1 in ( a ) was used to tune the four microwave-related parameters, and Case M2 is a validation case.

Techniques: Biomarker Discovery

$Experimentally measured temperatures and pressures for Cases SM1 and SM2 of Table , shown in ( a , c ) and ( b , c ) respectively. Lumped-capacitance model simulations are also shown in ( a ) and ( b ). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f1}$$\end{document} , \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f2}$$\end{document} , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f3}$$\end{document} are product temperature readings in different center vials; \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {vw}$$\end{document} is the temperature measured on the outside wall of a vial. Model curves terminate at predicted end of primary drying. In ( a ), the model \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$R_{p}$$\end{document} was adjusted to match product temperature readings. All microwave-related parameters are determined from Case M1 in Fig. below, so Case SM2 in ( b ) has no tuning parameters.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Experimentally measured temperatures and pressures for Cases SM1 and SM2 of Table , shown in ( a , c ) and ( b , c ) respectively. Lumped-capacitance model simulations are also shown in ( a ) and ( b ). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f1}$$\end{document} , \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f2}$$\end{document} , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f3}$$\end{document} are product temperature readings in different center vials; \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {vw}$$\end{document} is the temperature measured on the outside wall of a vial. Model curves terminate at predicted end of primary drying. In ( a ), the model \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$R_{p}$$\end{document} was adjusted to match product temperature readings. All microwave-related parameters are determined from Case M1 in Fig. below, so Case SM2 in ( b ) has no tuning parameters.

Techniques:

$Experimentally measured temperatures, ( a ), and pressures, ( b ), for the SM3 case of Table , with lumped-capacitance modeling results also shown in ( a ). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f1}$$\end{document} , \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f2}$$\end{document} , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f3}$$\end{document} are frozen product temperatures for different center vials. Model curves terminate at predicted end of drying. No parameter tuning was carried out based on these experimental results, so this serves as a validation case for the model.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Experimentally measured temperatures, ( a ), and pressures, ( b ), for the SM3 case of Table , with lumped-capacitance modeling results also shown in ( a ). \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f1}$$\end{document} , \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f2}$$\end{document} , and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_\text {f3}$$\end{document} are frozen product temperatures for different center vials. Model curves terminate at predicted end of drying. No parameter tuning was carried out based on these experimental results, so this serves as a validation case for the model.

Techniques: Biomarker Discovery

$Overlaid 13 C SSNMR spectra of lyophilized attenuated live virus vaccine formulations with regions used for \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_1$$\end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_{1\rho }$$\end{document} relaxation time analysis highlighted. Conventional results are from Cycle V1, and RF/Microwave results are from Cycle V2.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Overlaid 13 C SSNMR spectra of lyophilized attenuated live virus vaccine formulations with regions used for \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_1$$\end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_{1\rho }$$\end{document} relaxation time analysis highlighted. Conventional results are from Cycle V1, and RF/Microwave results are from Cycle V2.

Techniques: Virus

$Solid-state NMR \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_1$$\end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_{1\rho }$$\end{document} relaxation times for attenuated live virus formulations.$

Journal: Scientific Reports

Article Title: Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control

doi: 10.1038/s41598-025-91642-4

Figure Lengend Snippet: Solid-state NMR \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_1$$\end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^1H$$\end{document} \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$T_{1\rho }$$\end{document} relaxation times for attenuated live virus formulations.

Techniques: Virus

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